The story continues of Belinda (Sarah Jones), a rare female doctor working in a quaint Missouri town. When her longtime friend and colleague, Annie (Haylie Duff), arrives so that Belinda can watch over her in the last stages of her pregnancy, Annie brings along her mother-in-law, Mary (Patty Duke), a seen-it-all nursemaid whose homeopathic remedies and folksy wisdom are at odds with Belinda’s scientific knowledge.
As Belinda deals with the headaches Mary is causing, she must also address issues at home. While her adopted daughter discovers the joys and pains of a first love, Belinda and her husband (Jordan Bridges) find their own relationship is suffering over Belinda’s inability to get pregnant. Just as the town learned to put its faith in Belinda as their doctor, so too must Belinda learn to accept that the best guidance for her own problems may come from unlikely sources.